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KMID : 0378119780050010081
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Chungnam Medical Journal
1978 Volume.5 No. 1 p.81 ~ p.86
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A comparative Study of the Anthelmintic Effects of Oxantel/Pyrantel Suspension and Metcidazole in Multiple Infection of Intestinal Nematodes
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金鍾煥/Kim, Chong-Hwan
辛大煥/林定圭/Shin, Dae-Whan/Lim, Jung-Kyoo
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Abstract
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A total of 63 subjects with multiple intestinal nematode infection: T. trichiura, A. lumbricoides, E. vermicularis and T. orientalis were treated with Oxantel/Pyrantel suspension and Mebendazole.
The administration of Oxantel/Pyrantel suspension was 15mg/kg body weight in a single dose and Mebendazole was 600mg, divided by 100mg, twice daily for three consecutive days regardless of the body weight or ages.
The results of present trials are summarized as follows:
1. The egg negative conversion rates for Oxantel/Pyrantel suspension were 100% in 20 cases of Ascariasis and in 3 cases of T. orientalis infection, nrd 92. 3% in 26 cases of Enterobiasis. The egg reduction rate of T. trichiura was 84. 8%.
2. The Mebendazole treated group showed the egg negative conversion rates of 100
in 27 cases of Ascariasis and one case of Trichostrongyliasis, 88-590 in 26 cases of Enterobiasis and 19.4% in 2 cases of Trichuriasis. The egg reduction rate of T. trichiura was 89.4%.
3. With the Oxantel,%Pyrantel treated group, adult worms were found T. trichiura 1449(av. 45.K), A. lumbricoides 81 (av. 4. 1) and E. vermicularis 249 (av. 9.6) worms. In Mebendazole treated group demonstrated the number of adult worms: 406 (av. 13. 1) of T. trichiura, 79 (av. 2.9) of A. lumbricoides and I,A (av. 5. 2) of E. vermicularis, respectively.
4. Side effects of both Oxantel/Pyrantel and Mebendazole were few and mild.
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